Genome-wide predictions of autism-associated genes. Is a neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive patterns of behavior. ASD has a strong genetic basis. But we still lack the full complement of autism-associated genes. Here we present a genome-wide prediction. Based on known disease genes in the context of a human brain-specific gene interaction network.

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Genome-scale Integrated Analysis of gene Networks in Tissues. Relevant tissues for query genes. GIANT leverages a tissue-specific gold standard to automatically up-weight datasets relevant to a tissue from a large data compendium of diverse tissues and cell-types. The resulting functional networks accurately capture tissue-specific functional interactions. Troyanskaya Laboratory - Princeton University.

This server performs in silico nano-dissection, an approach we developed to identify genes with novel cell-lineage specific expression. This method leverages high-throughput functional genomics data from tissue homogenates to accurately predict genes enriched in specific cell types. Defining cell type specificity at the transcriptional level in human disease.

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